• 研究方向

    Research Direction

    翻译起始因子eIF3

    TRANSLATION INITIATION FACTOR eIF3

    我们关注eIF3在翻译起始、延伸和抑制中的典型和非典型作用，尤其对揭示eIF3在翻译、代谢和能量平衡中的特殊作用感兴趣。在过去三年的研究中，eIF3在mRNA翻译中的作用得到了广泛延伸。现在看来，这种多亚基复合物参与了mRNA翻译的每一种可能形式，控制着蛋白质合成的每一个步骤，如从起始到延伸再到蛋白质的质量控制。通过eIF3的研究，我们开始认识到蛋白质合成是一个高度集成的过程，它与蛋白质的合成、蛋白质的折叠、亚细胞靶向和降解相互协调。与此同时，eIF3亚基似乎在不同组织和单个细胞之间可能具有不同的特定功能。然而，关于eIF3在蛋白质合成中的亚基和组织特异性功能、以及它们受环境条件和翻译后修饰的调节作用，还需要做更深的了解。

     

    We are focusing on canonical and non-canonical roles of eIF3 in translation initiation, elongation, and repression. In particular, are interested in revealing the specific role of eIF3 in translation, metabolism, and energy balance. Studies over the past three years have substantially expanded the involvements of eIF3 in mRNA translation. It now appears that this multi-subunit complex is involved in every possible form of mRNA translation, controlling every step of protein synthesis from initiation to elongation, termination, and quality control in positive as well as negative fashion. Through the study of eIF3, we are beginning to appreciate protein synthesis as a highly integrated process coordinating protein production with protein folding, subcellular targeting, and degradation. At the same time, eIF3 subunits appear to have specific functions that probably vary between different tissues and individual cells. Much remains to be learned, however, about subunit and tissue-specific functions of eIF3 in protein synthesis and their regulation by environmental conditions and posttranslational modifications.

    蛋白质内稳态

    PROTEIN HOMEOSTASIS

    我们也在解决应激反应与蛋白质质量控制通路之间相互反应的这一难题。我们尤其感兴趣的是通过蛋白酶而实现蛋白质合成与降解的连接机制。我们发现翻译启始因子eIF3复合体与质量控制机制有关，它可能是通过核糖体与蛋白质的直接相互作用来实现的。目前，我们正在做一系列基因与生物化学的相关实验来揭示eIF3在蛋白质质量控制中所起的作用。

     

    We are also addressing the interaction of stress response and protein quality control pathways. In particular, we are interested in the coupling of protein synthesis and degradation by the proteasome. We have discovered that the translation initiation factor eIF3 complex is involved in this control, probably through direct interactions with ribosomes and the proteasome. We are performing genetic and biochemical experiments to unravel the role of eIF3 in protein quality control.

  • Publications

    Duan, H., Zhang, S., Zarai, Y., Öllinger, R., Wu, Y., Sun, L., Hu, C., He, Y., Tian, G., Rad, R., Kong, X., Cheng, Y., Tuller, T., & Wolf, D. A. (2023). eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content. The EMBO journal, 42(12), e112362- This article was cited here
     
    Hu, C., Lin, W., Zhao, K., Tian, G., Kong, X., Luo, G., Wolf, D. A., & Cheng, Y. (2023). NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma. iScience 26(4), 106531- This article was cited here
     
    Jain S, Hu C, Kluza J, Ke W, Tian G, Giurgiu M, Bleilevens A, Campos AR, Charbono A, Stickeler E, Maurer J, Holinski-Feder E, Vaisburg A, Bureik M, Luo G, Marchetti P, Cheng Y, Wolf DA. (2022) Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I. Cell Chem Biol 29(3):436-450 - This article was cited here
     
    Tian, G. Y.; Hu, C.; Yun, Y.; Yang, W.; Dubiel, W.; Cheng, Y.; Wolf, D. A. (2021) Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins. THE EMBO JOURNAL 40(13):e106183 - This article was cited here
     
    Wang, J.; Dubiel, D.; Wu, Y.; Cheng, Y.; Wolf, D.A.; Dubiel, W. (2021) CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response. Cell Reports 34(4):108662 - This article was cited here
     
    Lin, Y.Y.; Li, F.; Huang, L.; Polte, C.; Duan, H.; Fan, J.; Sun, L.; Xing, X.; Tian, G.; Cheng, Y.; Ignatova, Z.; Yang, X.; Wolf, D.A. (2020) eIF3 associates with 80S ribosomes to promote early translation elongation, mitochondrial homeostasis, and skeletal muscle health. Molecular Cell 79(4):575-587 - This article was cited here
     
    Wolf, D.A.; Lin, Y.Y.; Duan, H.; Cheng, Y. (2020) eIF-Three to tango: Emerging functions of translation initiation factor eIF3 in protein synthesis and disease. J. Molecular Cell Biology 12(6), 403-409 - This article was cited here
     
    Sanchez, M.; Lin, Y.Y.; Yang, C.-C.; McQuary, P.; Campos, A.R.; Aza-Blanc, P.; Wolf, D.A. (2019) Crosstalk between eIF2α and eEF2 phosphorylation pathways optimizes translational arrest in response to oxidative stress. iScience 20:466-480 - This article was cited here
     
    Ekholm-Reed, S.; Baker, R.; Campos, A.R.; Stouffer, D.; Henze, M.; Wolf, D.A.; Loring, J.F.; Thomas, E.A.; Reed, S.I.; (2019) Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice, Communications Biology 2:125 - This article was cited here
     
    Sanchez, M.; Xia, Z.; Rico-Bautista, E.; Cao, X.; Cuddy, M.; Castro, D.J.; Correa, R.G.; Chen, L.; Yu, J.; Bobkov, A.; Ruvolo, V.; Andreeff, M.; Oshima, R.G.; Matsuzawa, S.-I.; Reed, J.C.; Zhang, X.-K.; Hansel, D.; Wolf, D.A.; Dawson, M.I. (2018) Oxidized analogs of di(1H-indol-3-yl)methyl-4-substituted-benzenes are UPR-inducers with potent and safe anti-cancer activity. Oncotarget 9:25057 - 25074 - This article was cited here
     
    Dubiel, W.; Dubiel, D.; Wolf, D.A.; Naumann, M. (2018) Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation. Trends in Biochemical Sciences 43:95-107 - This article was cited here
     
    Straube, R.; Shah, M.; Flockerzi, D.; Wolf, D.A. (2017) Trade-off and flexibility in the dynamic regulation of the cullin-RING ligase repertoire. PLOS Computational Biology 13: e1005869 - This article was cited here
     
    Wolf, D.A.; Bahler, J.; Wise J.A. (2017) Schizosaccharomyces pombe polysome profile analysis and RNA purification. - This article was cited here
     
    Attali, I.; Tobelaim, W.S.; Persaud, A.; Motamedchaboki, K.; Simpson-Lavy, K.J.; Mashahreh, B.; Levin-Kravets, O.; Keren-Kaplan, T.; Pilzer, I.; Kupiec, M.; Wiener, R.; Wolf, D.A.; Rotin, D.; Prag, G. (2017) Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases. EMBO Journal 36:425-440 - This article was cited here
     
    Shah, M.; Su, D.; Scheliga, J.S.; Pluskal, T.; Boronat, S.; Motamedchaboki, K.; Campos, A.R.; Qi, F.; Yanagida, M.; Wolf, D.A. (2016) A transcript-specific eIF3 complex mediates global translational control of energy metabolism. Cell Reports 16:1891-1902 - This article was cited here
     
    Fan, J.B.; Arimoto, K.-I.; Motamedchaboki, K.; Yan, M.; Wolf, D.A.; Zhang, D.-E. (2015) Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis. Scientific Reports 5:12704 - This article was cited here
     
    Yang, C.-C.; Fazli, L.; Loguercio, S.; Zharkikh, I.; Aza-Blanc, P.; Gleave, M.E.; Wolf, D.A. (2015) Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass. Oncotarget 26:22060-22071 - This article was cited here
     
    Wolf, D.A. (2014) Is reliance on mitochondrial respiration a "chink in the armor" of therapy-resistant cancer? Cancer Cell 26, 788-795 - This article was cited here 
     
    Yang, C.-C.; Chung, A.; Brill, L.M.; Williams, R.; Wolf, D.A. (2014) Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation. F1000Research 3:115 - This article was cited here
    Rico-Bautista, E.; Zhu, W.; Kitada, S.; Ganapathy, S.; Lau, E.; Krajewski, S.; Ramirez, J.; Bush, J.A.; Yuan, Z.; Wolf, D.A. (2013) Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via unfolded protein response signaling. Oncotarget 4, 1212-1229 - This article was cited here 
     
    Wu, S..; Zhou, W.; Nhan, T.; Toth J.I.; Petroski, M.D.; Wolf, D.A. (2013) CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire. Nature Communications 4, 1642 - This article was cited here 
     
    Xia, Z.; Cao, X.; Rico-Bautista, E.; Yu, J.; Chen, L.; Chen, J.; Wolf. D.A.; Zhang, X.-K.; Dawson, M.I. (2013) Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability. Medicinal Chemistry Communications 4: 332-339 - This article was cited here
     
    Rico-Bautista, E.; Wolf, D.A. (2012) Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation. Chemistry & Biology 19, 1497-1498 (Preview invited) - This article was cited here
     
    Bauer, F.; Matsuyama, A.; Candiracci, J.; Dieu, M.; Scheliga, S.; Wolf, D.A.; Yoshida, M.; Hermand, D. (2012) Translational control of cell division by elongator. Cell Reports 1, 424-433 - This article was cited here
     
    Lackner, D.H.; Schmidt, M.W.; Wu, S.; Wolf, D.A., Bähler, J. (2012) Regulation of transcriptome, translation, and proteome in response to environmental stress in fission yeast. Genome Biology 13:R25 - This article was cited here
     
    Keren-Kaplan, T.; Attali, I., Motamedchaboki, K.; Davis, B.A.; Tanner, N., Reshef, Y., Laudon, E.; Kolot, M.; Levin-Kravets, O.; Kleifeld, O.; Glickman, M.; Horazdovsky, B.F.; Wolf, D.A., Prag, G. (2012) Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria. EMBO J.31, 378 - 390 - This article was cited here
     
    Petroski, M.D.; Salvesen, G.S.; Wolf, D.A. (2011) Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Proc. Natl. Acad. Sci. USA, 108, 1749-1750 (Commentary, invited) - This article was cited here
     
    Rico-Bautista, E.; Yang, C.-C.; Lu, L.; Roth, G.P.; Wolf, D.A. (2010) Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. BMC Biology 8:153 - This article was cited here
     
    Sha, Z.; Brill, L.M.; Cabrera, R.; Kleifeld, O.; Glickman, M.H.; Chang, E.C.; Wolf, D.A. (2009) The eIF3 Interactome Reveals the Translasome, a Supercomplex Linking Protein Synthesis and Degradation Machineries. Molecular Cell 36, 141-152 - This article was cited here
     
    Schmidt, M.W.; McQuary, P.R.; Wee, S.; Hofmann, K.; Wolf, D.A. (2009) F-box-directed CRL complex assembly and regulation by the CSN and CAND1. Molecular Cell 35,586-597 - This article was cited here
     
    Wu, S.; Wolf, D.A. (2009) Destruction of RhoA CULtivates Actin. Molecular Cell 35, 735-736 (Preview, invited) - This article was cited here
     
    Jones, M.R.; Quinton, L.J.; Blahna, M.T.; Neilson, J.R.; Fu, S.; Ivanov, A.R.; Wolf, D.A.; Mizgerd, J. (2009) Zcchc11-dependent uridylation of microRNA directs cytokine expression . Nature Cell Biology 11, 1157-1163 - This article was cited here
     
    Yang, C.-C.; Wolf, D.A. (2009) Inflamed Snail speed metastasis. Cancer Cell 15, 355-357 (Preview, invited) - This article was cited here
     
    Wolf, D.A.; Petroski, M.D. (2009) Rfu1, stimulus for the ubiquitin economy. Cell 137, 397-398 (Preview, invited) - This article was cited here
     
    Brill, L.M.; Motamedchaboki, K.; Wu S.; Wolf, D.A. (2009) Comprehensive proteomic analysis of Schizosaccharomyces pombe by two-dimensional HPLC-tandem mass spectrometry. Methods 48, 311-319 - This article was cited here
     
    Herzinger, T.; Wolf, D.A. (2009) Snail puts melanoma on the fast track. Pigment Cell and Melanoma Research 22, 150-151 - This article was cited here
     
    Schmidt, M.W.; Houseman, E.A.; Ivanov, A.R; Wolf, D.A. (2007) Comparative proteomic and transcriptomic profiling of the fission yeast Schizosaccharomyces pombe. Molecular Systems Biology, 3:79 - This article was cited here
     
    Zhou, C.; Arslan, F.; Wee, S.; Krishnan, S.; Ivanov, A.R.; Oliva, A.; Leatherwood, J.; Wolf, D.A. (2005) PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. BMC Biology, 3:14 - This article was cited here
     
    Wee, S.; Geyer, R.; Toda, T.; Wolf, D.A. (2005) CSN facilitates cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability. Nature Cell Biology 7, 387-391 (Full text not freely available, please see pre-publication history for final author manuscript) - This article was cited here
     
    Doud, M.K.; Schmidt, M.W.; Hines, D.; Naumann, C.; Kocourek, A.; Kashani-Poor, N.; Zeidler, R.; Wolf, D.A. (2004) Rapid prefractionation of complex protein lysates with centrifugal membrane adsorber units improves the resolving power of 2D-PAGE-based proteome analysis. BMC Genomics 5:25 - This article was cited here
     
    Wolf, D.A.; Wee, S.; Zhou, C. (2003) The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? Nature Cell Biology 5, 1029-1033 (Full text not freely available, please see pre-publication history for final author manuscript) - This article was cited here
     
    Schmidt, M.; Jain, A.; Wolf. D.A. (2003) Multidimensional proteomic analysis of proteolytic pathways involved in cell cycle control. In: Cell Cycle Checkpoint Control Protocols. Lieberman H. B. ed. New York: Humana Press (2003) Vol. 241: 235-245 - This article was cited here
     
    Geyer, R.; Wee, S.; Anderson, S.; Yates J.R.III; Wolf. D.A. (2003) BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Molecular Cell 12, 783-790 - This article was cited here
     
    Wolf, D.A.; Geyer, R. (2003) Dynamic release of Cdc34 from SCF: The hand that rocks the cradle. Cell 114, 532-533 (Preview, invited) - This article was cited here
     
    Zhou, C.; Wee, S.; Rhee, E.; Naumann, M.; Dubiel, W.; Wolf, D.A. (2003) Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Molecular Cell 11, 927-938 - This article was cited here
     
    Wee, S.; Hetfeld, B.; Dubiel, W.; Wolf, D.A. (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genetics 3:15 - This article was cited here
     
    Lu, L.; Schulz, H.; Wolf, D.A. (2002) The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells. BMC Cell Biology 3:22 - This article was cited here
     
    Seibert, V.; Prohl, C.; Schoultz, I.; Rhee, E.; Lopez, R.; Abderazzaq, K.; Zhou, C.; Wolf, D.A. (2002) Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p. BMC Biochemistry 3:22 -This article was cited here
     
    Zhou, C.; Seibert, V.; Geyer, R.; Rhee, E.; Lyapina, S.; Cope, G.; Deshaies, R.J.; Wolf, D.A. (2001) The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochemistry 2:7 - This article was cited he
    re
     
    Lyapina, S.; Cope, G.; Shevchenko, A.; Serino, G.; Tsuge, T.; Zhou, C.; Wolf, D. A.; Wei, N.; Shevchenko, A.; Deshaies, R. J. (2001). Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-1385 (Free upon registration) - This article was cited here
     

  • Joining Us!

    We are positively recruiting postdocs!

    Job Description 

       Postdoctoral Associate (multiple positions, applications will be considered until all positions are filled)

    What You Bring

    • A Ph.D. in biological sciences or a related field with a demonstrated record of high- quality productivity 
    • Ability to think creatively and independently about research problems 
    • Strong communication skills in English 
    • High degree of motivation and enthusiasm for academic research 
    • Utmost integrity in the conduct of research 
    • A background in computational biology/bioinformatics is a plus 

    What We Offer

    • An appreciative lab environment with individualized mentoring of each lab member 
    • A European-style academic environment with ample opportunity for scientific exchange and individual creativity 
    • Access to state-of-the-art research facilities and professionally managed shared resources 
    • A competitive compensation package at US pay scale  

    How to Apply

    To apply, please send the following documents in English as PDF files to dawolf@westlake.edu.cn

    • Resume

    • A ~1-page summary of research accomplishments

    • A bullet point description of research interests and postdoctoral training goals

    • Names, email addresses, and phone numbers of at least two references (ideally one being the Ph.D. advisor) – Do NOT provide reference letters

    • Doctoral degree certificate

    More information in https://www.westlake.edu.cn/Careers/OpenPositions/202301/t20230110_25092.shtml

  • Lab Members

  • broken image

    Dieter A. Wolf


    Professor, Westlake University

    1987~1995           M.D. Degree, Ludwig-Maximilians University Munich, Germany

    1992~1994           Independent research, Helmholtz Center Munich, Germany

    1994~1996           Postdoctoral Associate, Harvard Medical School

    1996~1998           Postdoctoral Associate, Stanford University School of Medicine

    1998~2007           Assistant/Associate Professor, Harvard School of Public Health

    2007~2019           Professor, Burnham Institute

    2015~2022           Distinguished Professor, Xiamen University, China

    2019~2022           Resident & Medical Head, Biomarker Program, Medical Genetics 

                                          Center Munich

    2021~present      Adjunct Group Leader, Technical University Munich

    2023~present      Professor, Westlake University

     

    broken image

    Haoran Duan


    Ph.D., Biochemistry, Xiamen University

    M.SC., Biochemistry, Xiamen University

    B.SC., China Pharmaceutical University

    broken image

    Cheng Hu


    Ph.D., Biochemistry, Xiamen University

    M.SC., Biochemistry, Xiamen University

    B.SC., Guizhou University

     

     

    broken image

    Jing Wang


    Ph.D., Biochemistry, Xiamen University

    M.SC., Biochemistry, Xiamen University

    B.SC., Northeast Forestry University

    broken image

    Fajin Li


    Ph.D., Tsinghua University

    B.SC., Tianjin Medical University

     

    broken image

    Reza Mohammadinejad

    Ph.D., Biomedical Sciences, Kerman University of Medical Sciences

    M.Sc., Biotechnology, Graduate University of Advanced Technology

    B.Sc., Plant Protection, Vali-e-Asr University

     

    broken image

    Mengyu Li


    (class of 2021)

    M.SC., Biology, New York University, NY, USA

    B.SC., Sichuan University, Chengdu, China

    broken image

    Xingjian Dong


    (class of 2022)

    B.SC., Huazhong Agricultural University

     

    broken image

    Changyi Shi


    (class of 2022)

    M.Med Zhejiang Laboratory of Animal Center, Hangzhou Institute of Medicine Chinese Academy of Sciences
    B.S China Pharmaceutical University

     

    broken image

    Yang Wu


    (class of 2023)

    M.SC The State University of New York, Stony Brook, NY, USA

    B.EN Southeast University, China

    broken image

    Fanglin Luo


    (class of 2023)

    B.SC., Shenyang Pharmaceutical University

    broken image

    Mangze Hu


    (class of 2023)

    M.SC., Immunology, Nantong University

    B.SC., Anhui University of Chinese Medicine

    broken image

    Tongtong Ba


    (class of 2023)

    M.SC.,Huazhong Agricultural University

     

    broken image

    Baochun Han


    PhD student of Xiamen University

    broken image

    Dan Su


    PhD student of Technical University of Munich

    broken image

    Yang Xiao


    broken image

    Danning Dai


    M.SC., Biomedical and Health Science, Monash University, Australia

    B.SC., Queen's University

    broken image

    Siqiong Zhang


    M.SC., Pharmacy, Xiamen University

    B.SC., Hubei University of Chinese Medicine

    broken image

    Bin Wei


    M.SC., Henan Agriculture University, China
    B.SC., Henan University of Animal Husbandry and Economy, China

    broken image

    Yixian Qin, Research assistant (2023~2024),

     

    broken image

    Shuhan Shi, Administrative Assistant (2022~2024),

     

    broken image

    Weimin Lin, Master Student (2020~2023),

    now Laboratory technician at Sahnghai Xihua Co., Ltd

    broken image

                                                                                        

    Yurui Zhang, Master Student (2019~2022),

    now PhD at Chinese Academy of Medical Sciences

     


     

     

     

    broken image

    Ran Liu, master student (2018~2021),

    now manager of Guangzhou Pharmaceutical Co., Ltd.

     

    Kemeng Zhao, master student (2018~2021),

    now working at Center of Disease Control and Prevention at Xiuzhou district, Jiaxing City.

     

    Yun Yun, master student (2018~2021),

    now working at Organisation Department of Jiangsu Provincial Party Committee.

    broken image

    Guiyou Tian, PhD Student (2016~2021),

    now Lecturer at Gannan Normal University

     

     

     

     

    broken image

    Linlu Huang, master student (2017~2020),

    now patent examiner at Fujian Sub-centre of Patent Examination Collaborative Centre

     

    Wei Ke,master student (2017~2020),

    now working at Statistics bureau at Chuzhou City

     

    Yanmeng Wu, master student (2017~2020),

    now working at Shanghai Tenth Hospital

    broken image

    Dan Su, master student (2014~2017),

    now PhD student at Technical University of Munich

     

    Yingying Lin, PhD student (2015~2019),

    now Assistant professor at Hangzhou Normal University

     

    Xiaosong Liu, master student (2016~2019),

    now PhD student at Intersectional Research Centre for Biology and Chemistry, Shanghai Institute of Organic Chemistry, CAS

     

    Li Sun, master student (2016~2019),

    now Thematic Head of Pharmacology at Zhaoyan New Drug Research and Development Centre

    broken image

    Warm Lab Family

    Work together!

    Study together!

    Make progress together!

    Together we make the world!

    broken image

    Our research benefits from global collaborators!

    Michal Shapira, Ben-Gurion University

    Roland Rad, Technical University of Munich

    Tamir Tuller, Tel-Aviv University

    Arkadii Vaisburg, Crocus Laboratories Inc

    Matthias Bureik, Tianjin University

    Reiko Sugiura, Kindai University

    Zoya Ignatova, University of Hamburg

    Wolfgang Dubiel, Charite University Hospital

    Xuerui Yang, Tsinghua University

    Yabin Cheng, Xiamen University

  • Contact Us

    Professor Dieter A. Wolf 
    E-mail：dawolf@westlake.edu.cn
    Address：No.18 Shilongshan Road Cloud Town,Xihu District, Hangzhou, Zhejiang PR China
    Post code：310024
    broken image
    broken image
    broken image
    broken image
    broken image
Cookie的使用
我们使用cookies来确保流畅的浏览体验。若继续，我们认为你接受使用cookies。
了解更多